Associate Professor Hideki Aihara

CBS Biochemistry
College of Biological Sciences
Twin Cities
Project Title: 
Structural Studies of DNA-Processing Enzymes

This research group is interested in DNA recombination, mutation, and repair processes relevant to human health. Specifically, they are currently pursuing the following processes:

  • Retroviral integration reaction by which retroviruses such as HIV-1 insert viral DNA into host chromosomes
  • Resolution of replicated hairpin telomeres in the Lyme disease spirochete Borrelia burgdorferi and other pathogenic bacteria
  • Repair of phosphotyrosyl-DNA adducts formed by failed topoisomerase reaction in eukaryotic organisms
  • DNA mutation by cytosine deamination catalyzed by the APOBEC3B enzyme

The researchers use X-ray crystallography to determine three-dimensional structures of protein-DNA complexes that represent intermediates of these DNA-processing reactions. The structural information is crucial for mechanistic understanding of aforementioned processes, which may ultimately aid in the development of new drugs or tools for genetic manipulations.

Project Investigators

Associate Professor Hideki Aihara
Thomas Bohl
Seunghee Cho
Kodai Hara
Timsi Rao
Ke Shi
Zhiqi Yin
 
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