Dr. Julio Alvarez

VETMD Vet Population Med
College of Veterinary Medicine
Twin Cities
Project Title: 
WGS Analysis of Nontyphoidal Salmonella and Surveillance of AMR in Salmonella and E. Coli

These researchers are using MSI for two projects:

  • The epidemiology and microevolution of nontyphoidal Salmonella from different sources (human, animal, food). The project's aim is to characterize Salmonella serotype 4,5,12:i:- isolates using whole genome sequencing techniques. This analysis uses data from over 700 Salmonella whole-genome sequences. The researchers will reconstruct a dated phylogenetic history of their population in order to assess the date of emergence of our population in question. In addition, they will model the evolution of population traits along this tree using Bayesian phylodynamic approaches. During 2018, the researchers have sequenced additional relevant S.4,5,12:i:- isolates to include in the analysis.
  • Study of the rise of antimicrobial resistance (AMR) for quinolones and extended-spectrum cephalosporins (two types of antibiotics) in Salmonella and Escherichia coli from Midwestern swine. The Salmonella analysis has been completed and is in review. The E. coli analyses is ongoing. The researchers are planning to extend their analysis to other livestock species and to humans. For this purpose, they are collaborating with the Minnesota Department of Health and are expecting to receive the WGS of Salmonella isolates from humans.

Project Investigators

Dr. Julio Alvarez
Ehud Elnekave
Shivdeep Singh Hayer
Seunghyun Lim
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