Assistant Professor Julio Alvarez

VETMD Vet Population Med
College of Veterinary Medicine
Twin Cities
Project Title: 
WGS Analysis of nontyphoidal Salmonella

This project is a continuation of the group's research looking at the epidemiology and microevolution of nontyphoidal Salmonella from different sources (human, animal, food).

The main objective of the project is to characterize Salmonella isolates from a population of interest using whole-genome sequencing techniques. The characterization will be done at an evolutionary level (phylogeny) and by looking at the antimicrobial resistance genes present in each genome. To do this, the researchers will assemble and align Salmonella isolates coming from the Minnesota Veterinary Diagnostic Lab (at least 192 isolates) and from different online sequence read archives (NCBI, ENA, etc.). In addition, they have 927 isolates that are in the process of being analyzed. A subset of these isolates (corresponding to an emergent serotype) will be used along with newly obtained isolates in order to perform a Bayesian phylodynamic analysis.

Project Investigators

Assistant Professor Julio Alvarez
Ehud Elnekave
Samuel Hong
Gustavo Machado
 
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