Assistant Professor Julio Alvarez

VETMD Vet Population Med
College of Veterinary Medicine
Twin Cities
Project Title: 
WGS Analysis of Nontyphoidal Salmonella and Surveillance of AMR in Salmonella and E. Coli

These researchers are using MSI for two projects:

  • A continuation of current research looking at the epidemiology and microevolution of nontyphoidal Salmonella from different sources (human, animal, food). The project's aim is to characterize Salmonella serotype 4,5,12:i:- isolates using whole genome sequencing techniques. This analysis uses data from over 700 Salmonella whole-genome sequences. The researchers will reconstruct a dated phylogenetic history of their population in order to assess the date of emergence of our population in question. In addition, they will model the evolution of population traits along this tree using Bayesian phylodynamic approaches.
  • Study of the rise of antimicrobial resistance (AMR) for quinolones and cephalosporins (two types of antibiotics) in Salmonella and Escherichia coli. Previous research showed an increase in the prevalence of antimicrobial resistance in livestock isolates obtained from the Minnesota Veterinary Diagnostic Lab. The goal is to explore this increase in phenotypic resistance at a molecular level, by sequencing, assembling and annotating a selection of over 150 isolates. Additionally, the researchers will assemble putative plasmids to investigate if the rise in AMR is mediated by specific plasmid elements.

Project Investigators

Assistant Professor Julio Alvarez
Ehud Elnekave
Shivdeep Singh Hayer
Samuel Hong
 
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