Dr. Jerrold Vitek

Neurology
Medical School
Twin Cities
Project Title: 
Parkinsons Disease - Signal Processing

There are several specific aims to this research:

  • The first aim is to characterize changes that occur in motor cortex (MC) and supplementary motor area (SMA) neuronal activity in the Parkinsonian state and during deep brain stimulation (DBS) in the region of the subthalamic nucleus (STN) under resting, passive, and active movement conditions in the MPTP monkey model of Parkinson's disease (PD).
  • The second aim is to characterize changes that occur in MC and SMA neuronal activity in the Parkinsonian state and during DBS in the region of the internal globus pallidus (GPi) under resting as well as passive and active movement conditions in the MPTP monkey model of PD and compare these changes to those that occur during STN DBS.
  • The third aim is to characterize the evolution of changes in neuronal activity in both the ipsilateral and contralateral MC and SMA during chronic unilateral stimulation in the STN and GPi and correlate these to the corresponding changes in bradykinesia and rigidity that occur on each side of the body in the MPTP monkey model of PD.

Project Investigators

Hannah Baker
Devyn Bauer
Adele DeNicola
Dr. David Escobar Sanabria
William Fryling
Dr. Claudia Hendrix PhD
Luke Johnson
Shane Nebeck
Zuzanna Pasek
Daniel Ryan
Marianne Scheitel
Dr. Jerrold Vitek
Dr. Jing Wang
Alec Werning
Lingling Yang
Ying Yu
 
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