This group's research focus is to improve outcomes in acute and chronic lung diseases. They use a combination of tools to understand the underlying mechanisms by which the lung repairs itself. A goal of these studies is to predict maladaptive lung repair and develop interventions to promote healthy repair.
The researchers are studying patients with Acute Respiratory Distress Syndrome (ARDS), a frequent cause of respiratory failure requiring supportive care in the intensive care unit. The lab is using state-of-the-art tools to perform the large-scale study of proteins in subjects with ARDS, to identify the biological processes and pathways that contribute to poor outcomes. They expect that these studies will result in novel therapy in ARDS through the identification of novel pathways that participate in lung repair.
The group has also begun comprehensive studies in patients with Sarcoidosis. Their goal is to characterize the protein profile in these patients and begin to understand why Sarcoidosis has such variable clinical presentation, response to treatment, and unpredictable course. These studies are designed to develop biomarkers that will inform about diagnosis and prognosis in Sarcoidosis.