Professor Anja Bielinsky

Project Title: 
Understanding the Replication Stress Signaling Network

Cancer cells experience constitutive replication stress, which drives genetic rearrangements and cancer genome evolution. One aspect that has remained unexplored is how cancer cells evade mitotic arrest in the presence of DNA damage. These researchers are utilizing budding yeast to explore the mechanisms of mitotic escape. Large genetic interaction screens have identified the SUMO-targeted ubiquitin ligase Slx5/Slx8 (in yeast) and RNF4 (in humans) as crucial players in this pathway. The researchers are now applying proteomic screens to identify the targets of these E3 ligases, which are evolutionarily highly conserved. The overarching goal of this research is to reveal vulnerabilities of cancer cells that can be exploited for new cancer therapies.

Project Investigators

Dr. Juan Abrahante - Llorens
Professor Anja Bielinsky
Ya-Chu Chang
Wendy Leung
Kevin Lin
Liangjun Wang
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