This group is focused on the mechanisms driving human natural killer (NK) cell differentiation and functional maturation. Some of this work involves genome-wide analyses such as whole-genome methylation arrays and RNA-seq. These researchers are currently studying the development of adaptive NK cells that arise in response to cytomegalovirus (CMV) infection. They have several ongoing projects to explore the ontology of these cells and the signaling pathways and transcription factor networks that define their identity. They are also working on whole-genome epigenetic analyses of demethylation during NK cell maturation and on single cell RNA-seq analyses of hematopoietic progenitor cells.