Spatiotemporal Dynamics of Cell Organization and Function
Cells have convoluted and dynamic morphologies. Their morphology is a critical element of the vast signaling network regulating cellular functioning. Focusing on cancer and immune cells, which are often highly dynamic, the Driscoll lab investigates how the interplay between cell morphology, dynamics, and signaling governs cell function. To visualize quick subcellular dynamics, they use state-of-the-art microscopy, especially high-resolution light-sheet microscopy. The detailed 3D movies produced by these microscopes necessitate dedicated computational pipelines, and so the group develops algorithms rooted in computer graphics, computer vision, and machine learning to facilitate biological discovery.