Neuronal networks, diversity, and specificity of function are important to both physiological processes and neurological disorders, including epilepsy and essential tremor. The Krook-Magnuson lab seeks to improve the understanding of how cells interact within a network, how networks interact with each other, and the physiological roles of neuronal populations. In this regard, key questions remain in epilepsy research, including what are the principal networks, conditions, and cell types involved in initiating, sustaining, propagating, terminating, and potentially suppressing, seizures. By improving our understanding of these, we improve the prospects of someday reaching the goal of no seizures, and no side effects, for all epilepsy patients. Similarly, basic questions regarding the development and expression of essential tremor remain.
The Krook-Magnuson lab uses rodent models of neurological disorders, including temporal lobe epilepsy and essential tremor, and techniques including electrophysiology, optogenetics, immunocytochemistry, calcium imaging, tissue clearing and whole brain imaging, transgenic animals, and behavioral experiments to address these fundamental questions.