Office of VP for Research
H. pylori infection and alcohol intake are important risk factors in gastric carcinogenesis; however, there is no direct experimental evidence that alcohol or H. pylori infection induces gastric cancer. These researchers are providing insight into the molecular mechanisms driving gastric carcinogenesis. Alcohol consumption, together with H. pylori infection, causes gastric cancer; interleukin-10 (IL-10) downregulation and mitochondrial metabolic dysfunction in CD8+ cells are also involved in carcinogenesis. IL-10 knockout accelerates the tumor development in combinational as well as in alone H. pylori infected or alcohol induced mice.