Familial, non-syndromic gliomas occur rarely; only 5% of subjects have a family history. Gliomas, especially the highly malignant types, may result in a life expectancy of less than one year. Present therapies have a limited effect in significantly improving mortality and morbidity. Very significant information on the genetics of glioma may be gained by studying these rare families. The researchers are doing whole-exone sequencing of these families.