College of Biological Sciences
This lab's work focuses on the discovery and heterologous expression of pathways and genes involved in the biosynthesis of metabolites from unique microbial sources. The researchers use cutting-edge and classical techniques in biochemistry, microbiology, metagenomics, and mass spectrometry to investigate unconventional peptide-based metabolites and pathways invoking radical-mediated chemistry. The new major project in the lab focuses on a new family of peptide metabolites encoded in basidiomycete fungal genomes. MSI resources crucial to this group's success include computing power and software for de novo peptide identification from LC-MS data as well as data management and analysis of sequenced microbial genomes. All in all, this research aims to tackle the exponentially expanding genomic universe for the discovery of new enzymology and therapeutics.