College of Veterinary Medicine
The Friedenberg lab studies complex/polygenic traits in dogs as models for similar diseases in humans. Their primary interest is in autoimmune diseases that target endocrine tissues and blood cells. Some of the specific diseases they study include Addison's disease (primary hypoadrenocorticism) and immune-mediated hemolytic anemia.
In addition to these autoimmune diseases, the lab is also collaborating with researchers at North Carolina State University, the University of California at Davis, Clemson University, and other institutions to inherited cardiac, neurologic, and neuromuscular diseases in dogs. Many of these diseases are complex traits as well. The group is also interested in canine population genetics more broadly, and are interested in developing resources that can help benefit other canine geneticists around the world.
Much of this work involves whole-genome sequencing, targeted resequencing, RNA-seq, long-read-length sequencing, and antigen receptor sequencing. This work uses MSI extensively.
Research by this group was featured on the MSI website in January 2021: Studying Genes to Help Dogs and Humans.