Associate Professor Daniel Harki

PHARM Medicinal Chemistry
College of Pharmacy
Twin Cities
Project Title: 
Development of Small Molecule and Nucleic Acid Probes

The Harki laboratory works across the chemistry-biology interface to design and develop novel, biologically active small molecules. One project in the laboratory is the development of non-natural nucleic acid probes to study dynamic processes of protein-DNA interactions, especially the interactions between the NF-kappaB transcription factor and DNA. The non-natural DNA oligonucleotides, prepared synthetically in the laboratory, are born largely out of computational-based design. The researchers are also developing small molecule and nucleic acid inhibitors of APOBEC3-family proteins, and protein-ligand docking are critical computational experiments we perform in this effort. Access to MSI resources greatly benefits this research program.

Project Investigators

Michael Grillo
Associate Professor Daniel Harki
Katherine Jones
Samantha Kennelly
Graduate School Fellow Kellan Passow
Angela Perkins
Sue Rathe
Jian Tang
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