Professor Kristin Hogquist

Lab Medicine & Pathology
Medical School
Twin Cities
Project Title: 
Thymic Selection

T lymphocytes acquire their essential characteristics during development in the thymus.  These properties—clonal expression of antigen receptors, major histocompatibility complex (MHC) restriction, self-tolerance, and lineage specific effector function—are continually established in the thymus as progenitors develop throughout the life of the animal. These researchers study how MHC restriction and self-tolerance are imprinted using genetically engineered mouse models. Current approaches include flow cytometry, microarrays, RNA-seq, and fluorescent imaging.

This research was featured on the MSI website in October 2014: Genetic Studies of Epstein-Barr Virus Infection.

Project Investigators

Sara Hamilton Hart
Dr. Christy Henzler
Professor Kristin Hogquist
Professor Stephen Jameson
Dr. Yu-Jung Lee
Ryan Martinez
Yan Xing
 
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