Professor Kris Hogquist

Lab Medicine & Pathology
Medical School
Twin Cities
Project Title: 
Thymic Selection

T lymphocytes acquire their essential characteristics during development in the thymus.  These properties - clonal expression of antigen receptors, major histocompatibility complex (MHC) restriction, self-tolerance, and lineage specific effector function - are continually established in the thymus as progenitors develop throughout the life of the animal. These researchers study how MHC restriction and self-tolerance are imprinted using genetically engineered mouse models. Current approaches include flow cytometry, RNA-seq, 10x Genomics scRNA-seq, and fluorescent imaging.

This research was featured on the MSI website in October 2014: Genetic Studies of Epstein-Barr Virus Infection.

Project Investigators

Dr. Juan Abrahante Llorens
Talia Dalzell
Samantha Graham
Dr. Sara Hamilton Hart
Dr. Christy Henzler
Professor Kris Hogquist
Professor Stephen Jameson
Rebecca LaRue
Ryan Martinez
Dr. Sarah Munro
Christine O'Connor
Oscar Salgado Barrero
Matous Voboril
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