College of Veterinary Medicine
Salmonellosis is the most common bacterial food-borne illness and current interventions have had little effect on the prevalence of this pathogen in swine or on the incidence of disease in humans. This probably is the result of the emergence of new strains of Salmonella enterica and the lack of known pathogen control points during animal production. This group's preliminary data have shown that pigs co-infected with S. enterica serovar Typhimurium and Lawsonia intracellularis shed higher levels of S. enterica and for a longer period of time. The group's hypothesis is that an L. intracellularis infection of pigs increases the risk of salmonellosis in humans. The goals of this project are to determine the duration and quantity of S. enterica shed by pigs co-infected with L. intracellularis and to determine if vaccination with an L. intracellularis-specific vaccine mitigates S. enterica shedding. A third goal is to quantify microbiome changes in the intestinal tract in response to infections with these two pathogens to identify new targets that could be exploited to reduce shedding of S. enterica.
The three specific aims of this project are:
- To determine the duration and quantity of S. enterica shed by pigs infected with S. enterica or S. enterica and L. intracellularis
- To determine the effect of vaccination against L. intracellularis on shedding S. enterica
- To determine intestinal microbiome changes in pigs that are singly and dually infected and with or without vaccination