College of Veterinary Medicine
This research focuses on understanding fundamental oncogenic mechanisms of human and canine aggressive sarcomas such osteosarcoma and angiosarcoma. Specifically, the researchers aim to establish chromatin accessibility and the mutational landscape that contribute to tumor-specific gene expression profiles in those sarcomas using next-generation sequencing technology. The group's comparative transcriptomic analyses demonstrate that there are molecular traits that regulate shared pathogenic pathways between human angiosarcoma and canine hemangiosarcoma. Their goal is to determine molecular mechanisms of how they create a niche that contribute to the development of osteosarcoma and angiosarcoma, and this will provide insights into the pathogenesis of these sarcomas.