College of Veterinary Medicine
This lab is interested in the functional genomics and molecular pathogenesis of a serious human and animal pathogen, Staphylococcus aureus, and antibacterial drug discovery. Specifically, they focus on different two-component signal transduction regulatory systems and several functional unknown essential proteins. Current efforts include determination of function of critical unknown genes and regulons for bacterial growth, multidrug resistance and pathogenesis, validational of novel antibacterial agents, and identification of host cell signaling pathways associated with pathogenicity during host-pathogen interaction. These efforts will provide new insight into the molecular and cellular mechanisms of pathogenicity, and may deliver unexploited targets for developing potent preventive and/or therapeutic agents against this life-threatening pathogen, including MSSA and MRSA, and benefit public health. In addition, they are actively involved in the identification of novel antibacterial agents by screening chemical compound library.