School of Dentistry
Of the class II HDACs, HDAC 4, 5, and 7 are more evolutionarily conserved with HDAC 4, 5, and 7 sharing approximately 57% similarity. In muscle cells, it has been shown that HDAC 4, 5, and 7 complement each other in order to regulate gene expression during various stages of muscle cell differentiation by changing localization in response to specific signals. However, since suppression of just HDAC7 enhances osteoclast formation, it suggests that the class II HDACs play distinct roles and cannot fully compensate for each other. Thus, one question that has emerged from this group's current work is whether are there different classes of genes in osteoclasts that are regulated by HDAC 4, 5, and 7.