Dr. Anna Selmecki PhD

Medical School
Twin Cities
Project Title: 
Genome Plasticity in Fungal Pathogen Genomics

Genome rearrangements resulting in copy number variation (CNV) and loss of heterozygosity (LOH) are frequently observed during the somatic evolution of cancer and promote rapid adaptation of fungi to novel environments. In human fungal pathogens, CNV and LOH can confer increased virulence and antifungal drug resistance, yet the mechanisms driving these rearrangements are not completely understood.

This research utilizes comparative genomics to determine what mechanisms promote genome rearrangements and how these rearrangements impact phenotype. The comparative genomics include analyses of thousands of clinical isolates, in vitro and in vivo evolved isolates during the acquisition of drug resistance. The transcriptomic analyses highlight how large genome changes impact gene expression and fitness.

Project Investigators

Laura Burrack
Katura Metzner
Ursula Oggenfuss
Nancy Scott
Dr. Anna Selmecki PhD
Travis Stratton
Robert Todd
Petra Vande Zande
Elizabeth Wash
Christopher Zajac
Xin Zhou
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