Dr Tate Gisslen

Pediatrics
Medical School
Twin Cities
Project Title: 
Transcriptomic Approach to Identify Altered Neuronal Gene Expression Induced by Prenatal Inflammation

The major goal of this work is to define genome-wide mechanisms in developing neurons that are potentially altered following a pro-inflammatory response. These researchers have established that significant systemic (i.e. non-brain) inflammation, measured in the liver and lung, occurs following prenatal LPS. Additionally, they found a decrease in glutamatergic receptors in the cerebral cortex, but without increased inflammation measured in the brain, leading to the conclusion that systemic inflammation affected the changes in neurotransmitter metabolism. Using this unique in vivo model, the researchers plan to determine how inflammation during fetal life alters the transcriptome of the developing cortex. Pathways elucidated might better define how systemic inflammation, without direct brain inflammation, affects cortical neurotransmitter systems. This information will enable them to identify and subsequently test specific pathways by which inflammation alters neurodevelopmental outcomes. MSI resources are being used for analysis of NGS data.

Project Investigators

Dr. Juan Abrahante - Llorens
Amanda Barks
Dr Tate Gisslen
Trevor Gould
Garima Singh
Principle Investigator Phu Tran PhD
 
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