Professor Jakub Tolar

Pediatrics
Medical School
Twin Cities
Project Title: 
RNA-seq

The researchers are working to characterize the skin environment of patients with Recessive Dystrophic Epidermolysis Bullosa (RDEB) in order to inform and improve treatment outcomes. Current work includes single-cell RNA-seq of patient fibroblasts, bulk RNA-seq of RDEB patient squamous cell carcinomas, and targeted resequencing of gene-corrected samples and of the gene responsible for RDEB, COL7A1. There are also several other sequencing projects for studying other diseases, such as ataxia, Fanconi anemia, and organ transplant-related squamous cell carcinoma. This lab owns a MiniSeq and produces a significant amount of sequencing data. They use MSI systems to analyze this data.

Project Investigators

Dr. Juan Abrahante - Llorens
Weili Chen
Allison Keith
Varvara Kirchner
Catherine Lee
Michael Pickett-Leonard
Julia Riedl
Elizabeth Thompson
Professor Jakub Tolar
Michael Vanden Oever
 
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