Mathematical Model of Molecular Interactions


MSI PI Casem Sarkar (associate professor, Biomedical Engineering) is the senior author on recently published research concerning molecular interactions. The authors developed a mathematical model to simulate the effects of key parameters controlling interactions between molecules with multiple binding sites. Such molecules are common in drug development. An article about this research appears on the University of Minnesota’s news site: Research Brief: Breakthrough Study on Molecular Interactions Could Improve Development of New Medicines. The paper can be found on the website of the Proceedings of the National Academy of Sciences of the United States of America: Mechanisms of Noncanonical Binding Dynamics in Multivalent Protein-Protein Interactions.

Professor Sarkar uses MSI resources for computational work related to elucidating fundamental biological design principles that underlie cellular decision making and to designing new molecular and cellular therapeutics for diseases.