Project abstract for group akkint

Reconstruction and Visualization of Brain From High-Resolution Optical Images

These researchers develop large-scale volumetric imaging of ex-vivo brain and reconstruct the nerve pathways in three dimensions. The optical system is a multi-contrast OCT that uses the polarization-maintaining fiber and polarization-sensitive measurements to produce multi-parametric images. The multiple contrasts provide the anatomical information, the differentiation between the gray matter and the white matter, the fiber architectures, and the quantification of fiber orientations in the brain. With integrated tissue sectioning between serial scans, the reseachers can reconstruct the brain with axial resolution of 5.5 μm and transverse resolution of ~ 15 μm. The axonal networks are visualized and fiber tracts of various scales are traced. 

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