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Familial Glioma - Genomic Studies

Familial, non-syndromic, gliomas occur rarely; only 5 % of subjects have a family history. Gliomas, especially the highly malignant types, may result in a life expectancy of less than one year. Present therapies have a limited effect in significantly improving mortality and morbidity. Very significant information on the genetics of glioma may be gained by studying these rare families. The University of Minnesota Department of Neurology's “Epilepsy and Glioma Study” has evaluated over 300 subjects with glioma and have so far ascertained three such families. In two they have completed whole-genome sequencing and identified some candidate genes that need further analysis and confirmation. A third family was identified (DNA was extracted in all members), with a very malignant form of glioma, glioblastoma multiform, and the researchers are doing whole-exon sequencing at the University of Minnesota Center for Human Genomics and at MSI.

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