Understanding the Replication Stress Signaling Network
Cancer cells experience constitutive replication stress, which drives genetic rearrangements and cancer genome evolution. One aspect that has remained unexplored is how cancer cells evade mitotic arrest in the presence of DNA damage. These researchers are utilizing budding yeast to explore the mechanisms of mitotic escape. Large genetic interaction screens have identified the SUMO-targeted ubiquitin ligase Slx5/Slx8 as a crucial player in this pathway. They are now applying proteomic screens to identify the targets of Slx5/Slx8, which is evolutionarily highly conserved and likely functions in an analogous way in human cells. The overarching goal of this research is to reveal vulnerabilities of cancer cells that can be exploited for new cancer therapies.
Return to this PI's main page.