Project abstract for group blekhman

Genomics Approaches for Understanding Host-Bacteria Interactions

The Blekhman lab’s research focuses on the intersection of human population genomics and metagenomics. They are interested in: understanding the role of host genetic variation in determining the composition of the microbiome; characterizing the cellular mechanisms involved in this interaction; elucidating the combined role of host genetics and the microbiota in susceptibility to complex disease; and shedding light on the evolutionary history of the symbiosis between humans and their microbiome. To achieve these goals, the researchers extensively use large-scale genomics datasets, and develop and apply computational, statistical, data mining, and populations genetics techniques.