The Buhlmann group is highly active in the development of electrochemical sensors. In particular, recent work in the field of ionophore-based ion-selective electrodes (ISEs) has greatly improved the understanding of the thermodynamics and kinetics that describe the response and selectivity of these sensors, which are used annually for over a billion measurements, mostly in clinical chemistry. These efforts resulted in the extension of detection limits from micro- to subpicomolar concentrations, improvements of selectivities by many orders of magnitude, and major advancements in biocompatibility and long-term stabilities. Over recent years, solving diffusion problems in currentless and applied current experiments has become increasingly important. For this purpose, this group is making increasing advantage of COMSOL. Important applications that will take advantage of COMSOL include modeling of the biofouling process of ISEs and the optimization of current pulse reference electrodes.
COMSOL will be used to explain experimental results on biofouling of ISEs. A quantitative explanation of the results will significantly improve the understanding of biofouling and will open ways to use ISEs for long-term implanting into the human body or long term monitoring in the environment.
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