Discovery of Bioactive Microbial Natural Products
The overarching goal of this research program is to discover novel natural products from bacteria and fungi. The researchers utilize a variety of biological assays (bacteria, fungi, and human cancer cells) to identify active compounds, and use a traditional bioassay-guided purification approach to obtain pure compounds. The group has focused especially on the discovery of anti-fungal compounds with the goal of developing new treatment options for drug-resistant Candida and Cryptococcus infections. An additional component of this work is to identify strains of bacteria and fungi collected from the environment that could be developed into biological control systems for animals and plant agriculture.
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