Project abstract for group cesalomo

Discovery of Bioactive Natural Products

The overarching goal of this research program is to discover novel natural products with useful biological activities. Chemical extracts are obtained from cultures of environmental bacterial and fungi that are collected from diverse field locations. Bioassay guided fractionation is used to purify compounds with activity against a panel of human bacterial and fungal pathogens, cancer cell lines, and pathogenic biofilms. Novel compounds with potent biological activities are studied to identify the critical pharmacophores which may provide lead structures for new therapeutics or strategies to treat infectious disease, cancer, and neurodegenerative disorders. Active compounds may also provide useful tools to study biosynthetic pathways, signaling cascades, drug resistance, and novel mechanisms of inhibition. Additional areas of interest include biocontrol of agricultural pathogens and the elucidation and modulation of communication networks among bacterial populations using natural products.