Project abstract for group fohlmeis

Multi-Dimensional (1-6D) Kinetics of Voltage-Gated Ion Channels in Central Neurons

This researcher has developed voltage-gating kinetic schemes for Sodium- and Potassium-channels in nerve (also muscle). This procedure will now be applied to the Hodgkin-Huxley model, whose behavior differs substantially from the previously studied mammalian channel-gating. Changes to Hodgkin-Huxley include 4D activation kinetics, and kinetic coupling of inactivation-gating for the sodium channel. These changes are based on the more recently gained knowledge of the molecular structure of ion channels. Preliminary results show that the higher-dimensional kinetics yield a virtually identical fit to the basic voltage-clamp data employed by Hodgkin and Huxley, while removing long-standing discrepancies between that model, and nerve behavior. The most significant of the removed discrepancies is the "stubbornly" tonic nature of the Hodgkin-Huxley model, relative to the highly phasic nature of the living preparation (the squid giant axon). MSI resources are employed for large-scale computation and graphics representations in the higher dimensional kinetic regimes.

A bibliography of this group’s publications is attached.

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