Proteomic Analysis Using Mass Spectrometry
In the evolving era of genome biology, mass spectrometry has emerged as a leading tool by which to measure the various properties of the protein products expressed by the genome. The complexity of biological systems however continually proves challenging to these existing methodologies, necessitating the development of novel tools to obtain the information required to gain a comprehensive understanding of these systems. The Griffin laboratory is interested in developing proteomics methods using mass spectrometry, providing new insights into mechanisms of cellular regulation and protein function. Among the ongoing projects in the Griffin lab is the development of new proteomic technologies and their application to saliva proteomics and oral cancer detection. A second objective is the development of a novel approach to study oxidative-stress induced carbonyl modification of proteins, providing new insights into an important aspect of cellular damage implicated in aging and disease. The group is also actively collaborating with MSI to develop new software and workflow tools for advanced applications in proteogenomics and metaproteomics.
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