Analysis of Genetic Data for the Identification of Genetic Factors in Chronic Disease
This Principal Investigator directs the Molecular Epidemiology and Biomarker Research Laboratory (MEBRL) and is a faculty investigator in the Advanced Research and Diagnostic Laboratory (ARDL). MEBRL acts as the central laboratory for several studies that apply biochemical, immunologic and genetic mass spectrometry (MS) and other techniques to the discovery, development, and application of biomarkers in cardiovascular disease, diabetes, and cancer. The researchers specialize in conducting analyses for large epidemiologic studies with the goal of defining new risk factors and understanding the pathophysiology of the conditions. One area of interest is the interplay of diet and chronic disease, in particular the role of oxidative cellular damage and antioxidant micronutrients in cardiovascular disease risk and prevention. Another research focus is the role of gene expression and genetic susceptibility in populations at risk for type-2 diabetes. The researchers are participating in major NIH-funded studies of genetic and environmental factors of people with type-2 diabetes in India and Singapore using genetic sequencing, genotyping, and analysis of biochemical receptors. One of the goals is to identify early onset type-2 diabetes in people ages 10 to 30 in order to initiate treatment and prevent or delay the development of cardiovascular complications.
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