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Project abstract for group haase
Vaccine to Concentrate Antibodies at the Mucosal Border
A vaccine is particularly urgently needed to prevent HIV-1 transmission to women. These researchers discovered that an attenuated vaccine that provides protection against vaginal challenge in the SIV-rhesus macaque animal model does so by locally producing antibodies to the virus and concentrating these antibodies on the path of virus entry by neonatal Fc receptor-mediated mechanisms operating in mucosal epithelium. This project's goal is to reproduce this system with safer immunogens and adjuvants. MSI resources are used for microarray analyses of vaccination on epithelium.