Project abstract for group halbergf

Assessment of Physiologic Chronomes From Womb to Tomb

Weeklong records of around-the-clock blood pressure and heart rate measurements obtained by ambulatory monitoring are analyzed by in-house chronobiologic software for a double purpose. First, abnormal patterns of variability in these variables assess cardiovascular disease risk in several outcome studies, some still ongoing in several cooperating centers worldwide. Focus here is placed on primary prevention, abnormalities occurring within the physiological range prompting the institution of prophylactic intervention. Treatment administration, in turn, can be optimized by timing, adjusted for each individual patient. Adjusting the kind and scheduling of treatment to the chronodiagnosis is a procedure that led to the concept of chronotheranostics. Second, combined with monitoring of the environment by physicists, environmental influences on human affairs can be studied. To the well-known synchronization by light and temperature of the circadian and circannual systems, this project on the BIOsphere and the COSmos (BIOCOS) adds the study of non-photic cycles in the environment stemming a.o., from corpuscular particles from the sun and space-terrestrial magnetism that share cycles found in biology. The systematic assessment of these “coperiodisms” is being documented in a repository or “atlas” of chronomes (broad time structures) in us and around us. This group's pursuit of these two main goals is greatly facilitated by access to the supercomputers to:

  • analyze long and dense data series
  • organize data into databases
  • automatically update reference standards as added data accumulate
  • detect the earliest risk by means of chronome alterations
  • follow-up at-risk individuals longitudinally by means of control charts
  • explore large parameter spaces in nonlinear analyses not requiring the specification of initial values


A bibliography of this group’s publications acknowledging MSI is attached.

In Memoriam:

MSI is sorry to note that the co-Principal Investigator for this group, Professor Franz Halberg, passed away on June 9, 2013. Professor Halberg was a pioneer in the field of chronobiology, the study of how natural biologic cycles affect health and life. He was a Principal Investigator and researcher at MSI for many years and published dozens of papers containing research that used MSI resources. MSI staff extend their deepest condolences to Professor Halberg's family, friends, and colleagues. An obituary is linked from the 6/19/13 MSI News story.