Project abstract for group hebbgupt

 

The Study of Gene Expression and miRNA Profile in Endothelial Cells

By using the technologies of RNA microarray, miRNA array, and pathway RT-PCR array combined with ingenuity pathway analysis, these researchers are trying to address the endothelial disfunction with regional endothelial heterogeneity that is central to the complex vascular pathobiology of sickle cell anemia. They are also trying to address whether the differences of endothelial responsiveness to shear stress between African Americans and Caucasian Americans is influenced genetically through continent-of-origin.