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Project abstract for group iaizzop
Modeling Phrenic Nerve Stimulation During Left-Sided Cardiac Pacing
Undesired phrenic nerve stimulation is a current limitation of cardiac resynchronization therapy (CRT), which involves a pacing lead placed in the coronary veins of the left ventricle. Phrenic nerve stimulation has been reported to occur in up to 35% of CRT patients. The purpose of this study is to determine the effect of coronary venous anatomy on phrenic nerve stimulation (PNS) by modeling resultant electric fields from various pacing positions. The researchers use Maxwell Software using MSI resources. They have performed in vivo studies to obtain inputs for the PNS models. They measured the voltage is takes to stimulate the nerve from a pacing position within the coronary veins and then characterized the anatomy of the pacing position using a microscribe and magnetic resonance imaging. Using Maxwell software, they will model the electric fields required to stimulate the phrenic nerve using tissue conductivities found in the literature. These models will provide insights on the effect of anatomy on PNS that can be incorporated in the development of CRT devices that can reduce phrenic nerve stimulation.
A bibliography of this group’s publications acknowledging MSI is attached.