Project abstract for group kaufman

Blood Cell Development

The main focus of this lab is to use human stem cells to both better understand basic mechanisms of human development, as well as to derive potentially novel therapeutic cell populations. The group's work uses human pluripotent stem cells as the starting point for most of these studies. They use both human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) to study development of blood cells and related cell populations. Projects include derivation of early hematopoietic cells, human lymphocytes, vascular cells, and mesenchymal cells. The researchers are also deriving new human iPSC lines from both normal and genetically abnormal individuals. Together, these projects provide exciting and innovative strategies to better understand human biology and produce new therapies.

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