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Project abstract for group kleinm0
Development of Novel p16INK4a Mimetics as Anticancer Therapy
This project utilizes MSI resources in the evaluation and design of peptides. The peptides are derived from a tumor suppressor, p16INK4a. The researchers' goal is to determine biophysical characteristics of peptides that have high efficacy in both inhibiting cyclin-dependent kinases 4 and 6 and also have good potential for intracellular entry into cancer cells and favorable pharmacokinetic parameters. The project uses programs for NMR-based determination of peptide structure and molecular dynamics studies of the peptides.