Project abstract for group kleinm0

Development of Novel p16INK4a Mimetics as Anticancer Therapy

This project utilizes MSI resources in the evaluation and design of peptides. The peptides are derived from a tumor suppressor, p16INK4a. The researchers' goal is to determine biophysical characteristics of peptides that have high efficacy in both inhibiting cyclin-dependent kinases 4 and 6 and also have good potential for intracellular entry into cancer cells and favorable pharmacokinetic parameters. The project uses programs for NMR-based determination of peptide structure and molecular dynamics studies of the peptides.