Structural and Molecular Basis of Human Diseases
This research focuses on the structural and molecular basis of human diseases including virus infections, cancer, and abnormal blood pressure. One line of research examines the invasion mechanisms of viruses. The researchers investigate the structures and functions of virus-surface proteins that mediate receptor recognition and cell entry of viruses. A second line of research explores the structural basis for cancer and abnormal blood pressure. Specifically, the group investigates the structures and functions of mammalian-cell-surface enzymes that are critical for tumor cell growth and blood pressure regulation. Based on these structural studies, the researchers further develop novel therapy strategies to treat human diseases. Their research tools include X-ray crystallography, electron microscopy, protein biochemistry, molecular virology, and vaccine and drug designs.
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