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Project abstract for group lifang
Structural Biology of Human Diseases
This research focuses on the structural biology of human diseases such as viral infections, cancer, and abnormal blood pressure. One line of research examines the receptor recognition mechanisms of viruses. The researchers investigate the structures and functions of virus-surface receptor-binding proteins and their interactions with host receptors. A second line of research explores the structural basis for cancer and abnormal blood pressure. Specifically, the group investigates the structures and functions of mammalian-cell-surface enzymes that are critical for tumor cell growth and blood pressure regulation. Based on these structural studies, the researchers further develop novel therapy strategies to treat human diseases. Their research tools include X-ray crystallography, protein biochemistry, molecular virology, cell biology, drug design, and animal experiments.
A bibliography of this group’s publications acknowledging MSI is attached.