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Project abstract for group matsuoh
Structural Studies of APOBEC Proteins and HIV Vif
Human APOBEC3G (A3G) proteins are capable of altering the HIV genome by deaminating cDNA cytosines to uracils. This activity can genetically inactivate the virus. As a counter-defense mechanism, HIV promotes the ubiquitin-mediated protein degradation of the A3 proteins. Degradation requires that the A3 proteins interact with the HIV virion infectivity factor (Vif) protein. Current studies have revealed substantial genetic and biochemical details of this host-pathogen conflict, but an atomic level understanding is still lacking. The major objectives of this research are to obtain a structural understanding of the DNA cytosine deaminase activity of A3 proteins and of the A3-Vif interaction.