Project abstract for group mcinteee

Designing Inhibitors for Low Molecular Weight Protein Tyrosine Phosphatase

Phosphatases are enzymes that are involved in the cell signal transduction process. When information is not properly conveyed in the cell, problems in the generation of signals necessary for different cellular events such as growth, migration, metabolism, gene transcription, cell-cell communication, ion channel activity, immune response, and apoptosis/survival decisions occur. When these events are not controlled, cancer and other disease states such as diabetes occur. Recent studies have assessed the role of low molecular weight (LMW) protein tyrosine phosphatases (PTP)s in cell transformation (conversion to cancerous cells). In these studies, it was shown that the expression of LWM PTP mRNA and protein is significantly increased in human breast, colon, bladder, and kidney tumor samples. Moreover, its enhanced expression generally predicted a more aggressive cancer. It has been suggested that LMW PTP may contribute to cancer invasivity (attacking adjacent tissues) by stabilizing cell-cell contacts. Inhibitors of LMW PTP hence may possess potential anti-cancer properties. The intent of this project is to design, make, and test compounds resembling pyridoxal 5’-phosphate (PLP). PLP is a known inhibitor of low molecular weight protein tyrosine phosphatase (LMW PTP). Inhibitors of LMW PTP may possess potential anti-cancer properties by inhibiting dephosphorylation (removal a phosphate group from a protein) of certain receptors. 

A bibliography of this group’s publications acknowledging MSI is attached.