You are here
Project abstract for group modianoj
Comparative Cancer Genetics
Comparative approaches using naturally occurring tumors of dogs, mice, and humans provide opportunities to discover evolutionarily conserved molecular abnormalities that contribute to the origin and progression of tumors. These researchers have documented such abnormalities in cytogenetically stable and cytogenetically chaotic tumors. They are now using high-throughput, genome-wide technologies to integrate aberrations that occur in the germ line, in the tumor genome, and in the tumor transcriptome to define functionally significant molecular subgroups of cancer for osteosarcoma, non-Hodgkin lymphoma, and soft tissue sarcomas (hemangiosarcoma). These data will be further integrated with pharmacogenomic approaches to validate the biological and therapeutic relevance of previously uncharacterized abnormalities.
A bibliography of this group’s publications acknowledging MSI is attached.