Project abstract for group ohlendor

<h3 class="red">Structural Analysis of Macromolecules</h3><p>The goal of these studies is to understand the structural basis of how macromolecules function. The current focus is on two groups of proteins: dixoygenases that use metal ions to cleave aromatic rings and proteins from gram-positive pathogens. Examples of dioxygenases are protocatechuate 3,4-dioxygenase (PCD), homoprotocatechuate 2,3-dioxygenase (HPCD), and 1,2-catechol dioxygenase (CTD). Examples of proteins from gram-positive pathogens are toxins and proteins involved in the formation of biofilms and in the tranfer of antibiotic resistance.</p><p>The researchers are refining structures of substrate and inhibitor complexes of mutants of PCD, HPCD, and CTD, and are solving and refining the structures of several proteins from pathogens.</p><p>Return to this PI&#39;s <a href="https://www.msi.umn.edu/pi/f3cdbb643eeacc4de97fb3016c4f43b1/19500">main page</a>.</p>