Structural Analysis of Macromolecules
The goal of these studies is to understand the structural basis of how macromolecules function. The current focus is on two groups of proteins: dixoygenases that use metal ions to cleave aromatic rings and proteins from gram-positive pathogens. Examples of dioxygenases are protocatechuate 3,4-dioxygenase (PCD), homoprotocatechuate 2,3-dioxygenase (HPCD), and 1,2-catechol dioxygenase (CTD). Examples of proteins from gram-positive pathogens are toxins and proteins involved in the formation of biofilms and in the tranfer of antibiotic resistance.
Return to this PI's main page.