Project abstract for group pankarne

Genetic Epidemiology of Cardiovascular Disease and Associated Risk Factors

This research project seeks to detect, localize, and characterize genes involved in the development of cardiovascular disease (CVD) and its associated risk factors (e.g., diabetes, high blood pressure, elevated blood cholesterol, metabolic syndrome, etc.). Recent technological advances in molecular biology and genetics have provided new opportunities to explore the genetic architecture of complex diseases and traits such as CVD. However, genetic epidemiological research on such traits requires data on tens of thousands of individuals, millions of genetic markers, and complex statistical models that are computationally demanding. The power of the supercomputer allows this group to construct models with higher order gene-gene or gene-environment interactions that cannot be practically evaluated using their own in-house computing resources and to conduct simulation experiments.

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