Project abstract for group sachsjn

<h3 class="red">Biophysics of Parkinsons and Cancer</h3><p>These researchers are continuing using MSI resources for three projects concerning membrane proteins.</p><ul><li>Investigation of how alpha-Synuclein, a protein involved in Parkinson&rsquo;s disease, alters the mechanical properties of synaptic vesicles. This research involves coarse-grained molecular dynamics simulations that will be among the largest ever published. This work will build on recent publications.</li><li>Studies of the conformational dynamics of Tumor Necrosis Factor Receptors using potential of mean force calculations. This work will also build on recently published research.</li><li>Simulations of a series of proteins, including alpha-Synuclein and Calmodulin in both oxidized and unoxidized states. This project involves longtime-scale all-atom MD simulations and involves University of Minnesota and MSI collaborators (<a href="https://www.msi.umn.edu/pi/409af224667365826e0b844e4f333764/35400">Jiali Gao</a>&nbsp;and <a href="https://www.msi.umn.edu/pi/2aa0d012af17521b6bd740cf0a4aaad2/10530">William Pomerantz</a>, both Department of Chemistry).</li></ul><p>Return to this PI&#39;s <a href="https://www.msi.umn.edu/pi/56c109d8459cbe14137152fc42d637e9/23915">main page</a>.</p>