Project abstract for group saltzman

Anti-Tumor Mechanisms of Attenuated Salmonella Typhimurium

Intravenous administration of nontoxic, virulence-attenuated strains of Salmonella enterica Typhimurium (S. Typhimurium) transformed with genes for immunomodulatory molecules reduce tumor burden in mouse models of cancer. This effect appears to be mediated by S. Typhimurium-induced increases in circulating and hepatic NK1.1+ lymphocytes as well as a variety of induced systemic cytokines. The purpose of this project is to further characterize the local and systemic immune response of S. Typhimurium strains expressing genes for various cytokines in a variety of murine experimental tumor models. The researchers use resources at MSI to plan and analyze genetic engineering aspects of this work.

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