Project abstract for group subraman

Elucidating the Molecular Mechanisms That Modulate the Anti-Cancer Immune Response and Control Malignant Transformation and Progression in Cancer

This research program can be broadly classified into four major complementary areas that intersect in each of the lab’s primary research projects:

  • Understanding the mechanism of malignant transformation and progression in colon cancer.
  • Elucidating the molecular mechanisms that modulate the anti-cancer immune response:.
  • Development of novel analysis tools and strategies to understand cancer gene regulation.
  • Identification and development of novel biomarkers and therapeutics in osteosarcoma.

The group has made significant advances in projects related to these areas, including the discovery of mechanisms that trigger malignant transformation and progression in colon cancer; human sarcoma pathobiology microRNA gene networks in cancer; and mechanisms that trigger osteosarcoma development and progression.

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