Project abstract for group subraman

Genomics of Colon Cancer

The discovery of microRNAs (miRNAs) has led to a paradigm shift in our basic understanding of gene regulation. It is apparent that miRNAs act as rheostats that fine-tune gene expression and maintain the functional balance of various gene networks. miRNA recognition elements (MREs) in coding and non-coding transcripts have evolved to become the cross talk hubs of gene interactions, affecting the expression levels and activities of different competing endogenous RNAs. Decoding the cross talk between MREs is critical to delineate the intricacies in gene regulation, and these researchers have just begun to unravel this complexity. 

A bibliography of this group’s publications acknowledging MSI is attached.