Project abstract for group tischler

Mycobacterium tuberculosis Persistance

These researchers are interested in how the bacterial pathogen Mycobacterium tuberculosis, which causes the pulmonary disease tuberculosis, avoids elimination by host immune responses to cause persistent infection. They use genetics of the bacterium and a murine infection model to identify and characterize M. tuberculosis persistence mechanisms. In particular, they are currently focusing on a signal transduction system that senses phosphate limitation and that is necessary for persistence. The group uses several software resources available through MSI (MacVector, GraphPad Prism) for data analysis. In the near future, they anticipate performing experiments using next-generation sequencing (ChIPseq and Tn-seq) and will use MSI resources for data storage and analysis.